Novel 18F Radiolabelled Tags for PET Imaging

Non-invasive Positron Emission Tomography imaging using Tri-fluoroborate tag molecules that efficiently and readily fluorinate any bio-molecule of choice.

Advantages

Advantages of the tag-molecule strategy.

  • Image a ligand or bio-molecule of choice through binding to a tag molecule.
  • The 18F radioisotope can be introduced in one mild and quick “wash-in” step.
  • A high radiochemical yield is obtained.
  • Allows for centralized manufacture and local stockpiling of tag molecules or tag molecule-biomolecule conjugates.

Applications in major clinical fields including oncology, neurology, and cardiology

  • Non-invasive, early diagnosis to determine disease type and extent.
  • Theranostic applications to tailor treatment based on individual diagnosis.
  • Non-invasive imaging in numerous research applications.

Technology Details

Positron Emission Tomography (PET), which involves the injection of short-lived radionucleotide-labelled tracer molecules into a patient, is the gold-standard of diagnostic imaging techniques. PET allows for non-invasive visualization of metabolic processes, such as cellular proliferation and neurological disorders. There are currently very few 18F-labelled molecules in regular clinical use, 18-fluorodeoxyglucose (FDG), a sugar derivative used to image cancer, is the imaging agent used in over 80% of PET procedures.  Currently the synthesis of 18F-labelled molecules involves high radioactive exposure, and the synthetic environment is incompatible with the labelling of most diagnostically relevant bio-molecules. Dr. David Perrin and co-workers have developed a platform strategy by which an exceptionally broad range of potential diagnostically relevant ligands (eg. small molecules, short DNA or RNA fragments, proteins, and antibodies) can be easily and quickly labelled with 18F and utilized for imaging purposes. The following scheme outlines the process of bio-molecule attachment, to a boron containing tag-molecule, and subsequent fluorination to create an individualized PET imaging agent.